Genetic susceptibility to type 2 diabetes and breast cancer risk in women of European and African ancestry.

ABSTRACT:

Background

Epidemiologic studies have reported a positive association between type 2 diabetes (T2D) and breast cancer risk, independent of body weight.

Methods

We investigated 40 genetic variants known to be associated with T2D in relation to breast cancer risk among 2,651 breast cancer cases and 2,520 controls of African or European ancestry that were pooled from seven studies.

Results

We found that two T2D risk alleles in Caucasian women (rs5945326-G, rs12518099-C) and one in women of African ancestry (rs7578597-T) were positively associated with breast cancer risk at a nominal significance level of 0.05, whereas two T2D risk alleles were inversely associated with breast cancer risk in Caucasian women (rs1111875-C, rs10923931-T). The composite T2D susceptibility sco

SUBMITTER: Hou N 

PROVIDER: S-EPMC3297695 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature