Ontology highlight
ABSTRACT:
SUBMITTER: Wu LJ
PROVIDER: S-EPMC3314139 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Wu Long-Jun LJ Wu Gongxiong G Akhavan Sharif M Reza MR Baker Amanda A Jia Yonghui Y Fahey Frederic H FH Luo Hongbo R HR Feener Edward P EP Clapham David E DE
Nature neuroscience 20120304 4
Phagocytic cell NADPH oxidase (NOX) generates reactive oxygen species (ROS) as part of innate immunity. Unfortunately, ischemia can also induce this pathway and inflict damage on native cells. The voltage-gated proton channel Hv1 enables NOX function by compensating cellular loss of electrons with protons. Accordingly, we investigated whether NOX-mediated brain damage in stroke can be inhibited by suppression of Hv1. We found that mouse and human brain microglia, but not neurons or astrocytes, e ...[more]