The Regulatory Network of Pseudomonas aeruginosa.

ABSTRACT:

Background

Pseudomonas aeruginosa is an important bacterial model due to its metabolic and pathogenic abilities, which allow it to interact and colonize a wide range of hosts, including plants and animals. In this work we compile and analyze the structure and organization of an experimentally supported regulatory network in this bacterium.

Results

The regulatory network consists of 690 genes and 1020 regulatory interactions between their products (12% of total genes: 54% sigma and 16% of transcription factors). This complex interplay makes the third largest regulatory network of those reported in bacteria. The entire network is enriched for activating interactions and, peculiarly, self-activation seems to occur more prominent for transcription factors (TFs), which contrasts

SUBMITTER: Galan-Vasquez E 

PROVIDER: S-EPMC3348663 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature