Identification of combinatorial patterns of post-translational modifications on individual histones in the mouse brain.

ABSTRACT: Post-translational modifications (PTMs) of proteins are biochemical processes required for cellular functions and signalling that occur in every sub-cellular compartment. Multiple protein PTMs exist, and are established by specific enzymes that can act in basal conditions and upon cellular activity. In the nucleus, histone proteins are subjected to numerous PTMs that together form a histone code that contributes to regulate transcriptional activity and gene expression. Despite their importance however, histone PTMs have remained poorly characterised in most tissues, in particular the brain where they are thought to be required for complex functions such as learning and memory formation. Here, we report the comprehensive identification of histone PTMs, of their combinatorial patterns, and o

SUBMITTER: Tweedie-Cullen RY 

PROVIDER: S-EPMC3365036 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature