Mediational relations between 12-Step attendance, depression and substance use in patients with comorbid substance dependence and major depression.

ABSTRACT:

Aims

Among patients with substance dependence and comorbid major depressive disorder (MDD) receiving treatment in a controlled trial, we examined if group differences in depression were mediated by 12-Step involvement, and if the effects of 12-Step involvement on future alcohol and drug use were mediated by reductions in depression.

Design

Controlled trial of Twelve-Step facilitation (TSF) and integrated cognitive-behavioral therapy (ICBT), delivered in out-patient groups for 6 months with adjunct pharmacotherapy.

Setting

Out-patient dual diagnosis clinic in Veteran's Affairs Healthcare Center.

Participants

Veterans (n = 209) diagnosed with alcohol, stimulant or marijuana dependence and substance-independent MDD.

Measurements

Twelve-Step attendance and a

SUBMITTER: Worley MJ 

PROVIDER: S-EPMC3466338 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature