Sympathetic hyperactivity influences chemosensor function in patients with end-stage renal disease.

ABSTRACT:

Background

Autonomic neuropathy is common in patients suffering from end-stage renal disease (ESRD). This may in part explain the high cardiovascular mortality in these patients. Chemosensory function is involved in autonomic cardiovascular control and is mechanistically linked to the sympathetic tone.

Objective

The aim of the present study was to assess whether sympathetic hyperactivity contributes to an altered chemosensory function in ESRD.

Material and methods

In a randomized, double-masked, placebo controlled crossover design we studied the impact of chemosensory deactivation on heart rate, blood pressure and oxygen saturation in 10 ESRD patients and 10 age and gender matched controls. The difference in the R-R intervals divided by the difference in the oxygen pr

SUBMITTER: Meyer C 

PROVIDER: S-EPMC3521372 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature