Differential gene expression profiling and biological process analysis in proximal nerve segments after sciatic nerve transection.

ABSTRACT: After traumatic injury, peripheral nerves can spontaneously regenerate through highly sophisticated and dynamic processes that are regulated by multiple cellular elements and molecular factors. Despite evidence of morphological changes and of expression changes of a few regulatory genes, global knowledge of gene expression changes and related biological processes during peripheral nerve injury and regeneration is still lacking. Here we aimed to profile global mRNA expression changes in proximal nerve segments of adult rats after sciatic nerve transection. According to DNA microarray analysis, the huge number of genes was differentially expressed at different time points (0.5 h-14 d) post nerve transection, exhibiting multiple distinct temporal expression patterns. The expression changes of

SUBMITTER: Li S 

PROVIDER: S-EPMC3578805 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature