Protein microarray analysis of cytokine expression changes in distal stumps after sciatic nerve transection.

ABSTRACT: A large number of chemokines, cytokines, other trophic factors and the extracellular matrix molecules form a favorable microenvironment for peripheral nerve regeneration. This microenvironment is one of the major factors for regenerative success. Therefore, it is important to investigate the key molecules and regulators affecting nerve regeneration after peripheral nerve injury. However, the identities of specific cytokines at various time points after sciatic nerve injury have not been determined. The study was performed by transecting the sciatic nerve to establish a model of peripheral nerve injury and to analyze, by protein microarray, the expression of different cytokines in the distal nerve after injury. Results showed a large number of cytokines were up-regulated at different time p

SUBMITTER: Cheng XQ 

PROVIDER: S-EPMC6921340 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature