Adipose tissue attracts and protects acute lymphoblastic leukemia cells from chemotherapy.

ABSTRACT: Obesity is associated with an increased risk of acute lymphoblastic leukemia (ALL) relapse. Using mouse and cell co-culture models, we investigated whether adipose tissue attracts ALL to a protective microenvironment. Syngeneically implanted ALL cells migrated into adipose tissue within ten days. In vitro, murine ALL cells migrated towards adipose tissue explants and 3T3-L1 adipocytes. Human and mouse ALL cells migrated toward adipocyte conditioned media, which was mediated by SDF-1?. In addition, adipose tissue explants protected ALL cells against daunorubicin and vincristine. Our findings suggest that ALL migration into adipose tissue could contribute to drug resistance and potentially relapse.

SUBMITTER: Pramanik R 

PROVIDER: S-EPMC3622767 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature