Transcriptome analysis of skin photoaging in chinese females reveals the involvement of skin homeostasis and metabolic changes.

ABSTRACT:

Background

Photoaging is cumulative damage to skin, caused by chronic, repeated solar radiation exposure. Its molecular mechanisms are poorly understood at the level of global gene expression.

Objective

This study set out to uncover genes and functional modules involved in photoaging at the level of transcription, with the use of skin samples from Chinese women.

Methods

Using the Illumina microarray platform, we compared the genome-wide expression profiles of 21 pairs of sun-exposed pre-auricular and sun-protected post-auricular skin samples from northern Chinese women.

Results

With microarray analysis, 1,621 significantly regulated genes due to photoaging were identified from skin samples. These genes were subjected to functional enrichment analyses with both

SUBMITTER: Yan W 

PROVIDER: S-EPMC3634825 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature