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Self-powered microfluidic chips for multiplexed protein assays from whole blood.

ABSTRACT: We report herein on a self-powered, self-contained microfluidic-based chip designed to separate plasma from whole blood, and then execute an assay of a multiplexed panel of plasma biomarker proteins. The power source is based upon a chemical reaction that is catalytically triggered by the push of a button on the chip. We demonstrate assays of a dozen blood-based protein biomarkers using this automated, self-contained device. This platform can potentially permit high throughput, accurate, multiplexed blood diagnostic measurements in remote locations and by minimally trained individuals.

SUBMITTER: Qin L

PROVIDER: S-EPMC3651861 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature

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Self-powered microfluidic chips for multiplexed protein assays from whole blood.

Qin Lidong L Vermesh Ophir O Shi Qihui Q Heath James R JR

Lab on a chip 20090416 14

We report herein on a self-powered, self-contained microfluidic-based chip designed to separate plasma from whole blood, and then execute an assay of a multiplexed panel of plasma biomarker proteins. The power source is based upon a chemical reaction that is catalytically triggered by the push of a button on the chip. We demonstrate assays of a dozen blood-based protein biomarkers using this automated, self-contained device. This platform can potentially permit high throughput, accurate, multipl ...[more]

PMID: 19568669

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