Determination of burn patient outcome by large-scale quantitative discovery proteomics.

ABSTRACT:

Objectives

Emerging proteomics techniques can be used to establish proteomic outcome signatures and to identify candidate biomarkers for survival following traumatic injury. We applied high-resolution liquid chromatography-mass spectrometry and multiplex cytokine analysis to profile the plasma proteome of survivors and nonsurvivors of massive burn injury to determine the proteomic survival signature following a major burn injury.

Design

Proteomic discovery study.

Setting

Five burn hospitals across the United States.

Patients

Thirty-two burn patients (16 nonsurvivors and 16 survivors), 19-89 years old, were admitted within 96 hours of injury to the participating hospitals with burns covering more than 20% of the total body surface area and required at least one

SUBMITTER: Finnerty CC 

PROVIDER: S-EPMC3660437 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature