Metabolic and cardiovascular genes in polycystic ovary syndrome: a candidate-wide association study (CWAS).

ABSTRACT: The role of metabolic disturbance in polycystic ovary syndrome (PCOS) has been well established, with insulin resistance and the resulting compensatory hyperinsulinemia thought to promote hyperandrogenemia. Genome-wide association studies (GWAS) have established a large number of loci for metabolic conditions such as type 2 diabetes and obesity. A subset of these loci has been investigated for a role in PCOS; these studies generally have not revealed a confirmed role for these loci in PCOS risk. However, a large scale investigation of genes related to these pathways has not previously been performed. We conducted a two stage case control association study of 121,715 single nucleotide polymorphisms (SNPs) selected to represent susceptibility loci associated with traits such as type 2 diabet

SUBMITTER: Jones MR 

PROVIDER: S-EPMC3689580 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature