Prospective associations between brain activation to cocaine and no-go cues and cocaine relapse.

ABSTRACT:

Background

The ability to predict potential for relapse to substance use following treatment could be very useful in targeting aftercare strategies. Recently, a number of investigators have focused on using neural activity measured by fMRI to predict relapse propensity. The purpose of the present study was to use fMRI to investigate prospective associations between brain reactivity to cocaine and response inhibition cues and relapse to cocaine use.

Methods

Thirty cocaine-dependent participants with clean cocaine urine drug screens (UDS) completed a baseline fMRI scan, including a cocaine-cue reactivity task and a go no-go response inhibition task. After participating in a brief clinical trial of d-cycloserine for the facilitation of cocaine-cue extinction, they returned for

SUBMITTER: Prisciandaro JJ 

PROVIDER: S-EPMC3703628 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature