Ontology highlight
ABSTRACT:
SUBMITTER: Boyer N
PROVIDER: S-EPMC3728915 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Boyer Nicolas N Morrison Karen C KC Kim Justin J Hergenrother Paul J PJ Movassaghi Mohammad M
Chemical science 20130401 4
The epipolythiodiketopiperazine (ETP) alkaloids are a highly complex class of natural products with potent anticancer activity. Herein, we report the application of a flexible and scalable synthesis, allowing the construction of dozens of ETP derivatives. The evaluation of these compounds against cancer cell lines in culture allows for the first expansive structure-activity relationship (SAR) to be defined for monomeric and dimeric ETP-containing natural products and their synthetic cognates. Ma ...[more]