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Autonomous molecular cascades for evaluation of cell surfaces.

ABSTRACT: Molecular automata are mixtures of molecules that undergo precisely defined structural changes in response to sequential interactions with inputs. Previously studied nucleic acid-based automata include game-playing molecular devices (MAYA automata) and finite-state automata for the analysis of nucleic acids, with the latter inspiring circuits for the analysis of RNA species inside cells. Here, we describe automata based on strand-displacement cascades directed by antibodies that can analyse cells by using their surface markers as inputs. The final output of a molecular automaton that successfully completes its analysis is the presence of a unique molecular tag on the cell surface of a specific subpopulation of lymphocytes within human blood cells.

SUBMITTER: Rudchenko M

PROVIDER: S-EPMC3776593 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature

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Autonomous molecular cascades for evaluation of cell surfaces.

Rudchenko Maria M Taylor Steven S Pallavi Payal P Dechkovskaia Alesia A Khan Safana S Butler Vincent P VP Rudchenko Sergei S Stojanovic Milan N MN

Nature nanotechnology 20130728 8

Molecular automata are mixtures of molecules that undergo precisely defined structural changes in response to sequential interactions with inputs. Previously studied nucleic acid-based automata include game-playing molecular devices (MAYA automata) and finite-state automata for the analysis of nucleic acids, with the latter inspiring circuits for the analysis of RNA species inside cells. Here, we describe automata based on strand-displacement cascades directed by antibodies that can analyse cell ...[more]

PMID: 23892986

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