Synthesis and evaluation of phosphorodithioate-based hydrogen sulfide donors.

ABSTRACT: A series of O-aryl- and alkyl-substituted phosphorodithioates were designed and synthesized as hydrogen sulfide (H2S) donors. H2S releasing capability of these compounds was evaluated using fluorescence methods. O-aryl substituted donors showed slow and sustained H2S release while O-alkylated compounds showed very weak H2S releasing capability. We also evaluated donors' protective effects against hydrogen peroxide (H2O2)-induced oxidative damage in myocytes and donors' toxicity toward B16BL6 mouse melanoma cells.

SUBMITTER: Park CM 

PROVIDER: S-EPMC3789624 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature