Hydrogen Sulfide Donors Activated by Reactive Oxygen Species.

ABSTRACT: Hydrogen sulfide (H₂ S) exhibits promising protective effects in many (patho)physiological processes, as evidenced by recent reports using synthetic H₂ S donors in different biological models. Herein, we report the design and evaluation of compounds denoted PeroxyTCM, which are the first class of reactive oxygen species (ROS)-triggered H₂ S donors. These donors are engineered to release carbonyl sulfide (COS) upon activation, which is quickly hydrolyzed to H₂ S by the ubiquitous enzyme carbonic anhydrase (CA). The donors are stable in aqueous solution and do not release H₂ S until triggered by ROS, such as hydrogen peroxide (H₂ O₂ ), superoxide (O₂^- ), and peroxynitrite (ONOO^- ). W

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC5175466 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature