Vitamin D3 supplementation for 16 weeks improves flow-mediated dilation in overweight African-American adults.

ABSTRACT:

Background

A growing body of evidence has linked vitamin D deficiency to increased risk of cardiovascular disease. Vitamin D deficiency is also more common in African Americans for whom an increased cardiovascular disease risk exists. This study sought to test the hypothesis that 16 weeks of 60,000 IU monthly supplementation of oral vitamin D(3) would improve flow-mediated dilation (FMD) in African Americans, whereas no change would be observed in the placebo group.

Methods

A randomized, double-blind, placebo-controlled clinical trial was conducted. Fifty-seven African-American adults were randomly assigned to either the placebo group or vitamin D group.

Results

Following 16 weeks of placebo (n = 23; mean age 31 ± 2 years) or 60,000 IU monthly oral vitamin D(3) (n = 2

SUBMITTER: Harris RA 

PROVIDER: S-EPMC3812921 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature