Ontology highlight
ABSTRACT:
SUBMITTER: Laurent G
PROVIDER: S-EPMC3838178 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Molecular and cellular biology 20130916 22
Sirtuins are a family of protein deacetylases, deacylases, and ADP-ribosyltransferases that regulate life span, control the onset of numerous age-associated diseases, and mediate metabolic homeostasis. We have uncovered a novel role for the mitochondrial sirtuin SIRT4 in the regulation of hepatic lipid metabolism during changes in nutrient availability. We show that SIRT4 levels decrease in the liver during fasting and that SIRT4 null mice display increased expression of hepatic peroxisome proli ...[more]