The Nordic long-term OCD treatment study (NordLOTS): rationale, design, and methods.

ABSTRACT:

Background

This paper describes and discusses the methodology of the Nordic long-term OCD-treatment study (NordLOTS). The purpose of this effectiveness study was to study treatment outcome of CBT, to identify CBT non- or partial responders and to investigate whether an increased number of CBT-sessions or sertraline treatment gives the best outcome; to identify treatment refractory patients and to investigate the outcome of aripiprazole augmentation; to study the outcome over a three year period for each responder including the risk of relapse, and finally to study predictors, moderators and mediators of treatment response.

Methods

Step 1 was an open and uncontrolled clinical trial with CBT, step 2 was a controlled, randomised non-blinded study of CBT non-responders from step

SUBMITTER: Thomsen PH 

PROVIDER: S-EPMC3878347 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature