Genetic variants influencing circulating lipid levels and risk of coronary artery disease.

ABSTRACT:

Objective

Genetic studies might provide new insights into the biological mechanisms underlying lipid metabolism and risk of CAD. We therefore conducted a genome-wide association study to identify novel genetic determinants of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides.

Methods and results

We combined genome-wide association data from 8 studies, comprising up to 17 723 participants with information on circulating lipid concentrations. We did independent replication studies in up to 37 774 participants from 8 populations and also in a population of Indian Asian descent. We also assessed the association between single-nucleotide polymorphisms (SNPs) at lipid loci and risk of CAD in up to 9 633 cases and 38 684 co

SUBMITTER: Waterworth DM 

PROVIDER: S-EPMC3891568 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature