Ontology highlight
ABSTRACT:
SUBMITTER: Hartshorn CM
PROVIDER: S-EPMC3980468 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Analytical chemistry 20130820 17
We compare a coherent Raman imaging modality, broadband coherent anti-Stokes Raman scattering (BCARS) microscopy, with spontaneous Raman microscopy for quantitative and qualitative assessment of multicomponent pharmaceuticals. Indomethacin was used as a model active pharmaceutical ingredient (API) and was analyzed in a tabulated solid dosage form, embedded within commonly used excipients. In comparison with wide-field spontaneous Raman chemical imaging, BCARS acquired images 10× faster, at highe ...[more]