Dataset Information
Peanut, milk, and wheat intake during pregnancy is associated with reduced allergy and asthma in children.
Ontology highlight
ABSTRACT: Background
Maternal diet during pregnancy may affect childhood allergy and asthma.Objective
We sought to examine the associations between maternal intake of common childhood food allergens during early pregnancy and childhood allergy and asthma.Methods
We studied 1277 mother-child pairs from a US prebirth cohort unselected for any disease. Using food frequency questionnaires administered during the first and second trimesters, we assessed maternal intake of common childhood food allergens during pregnancy. In mid-childhood (mean age, 7.9 years), we assessed food allergy, asthma, allergic rhinitis, and atopic dermatitis by questionnaire and serum-specific IgE levels. We examined the associations between maternal diet during pregnancy and childhood allergy and asthma. We also examined the cross-sectional associations between specific food allergies, asthma, and atopic conditions in mid-childhood.Results
Food allergy was common (5.6%) in mid-childhood, as was sensitization to at least 1 food allergen (28.0%). Higher maternal peanut intake (each additional z score) during the first trimester was associated with 47% reduced odds of peanut allergic reaction (odds ratio [OR], 0.53; 95% CI, 0.30-0.94). Higher milk intake during the first trimester was associated with reduced asthma (OR, 0.83; 95% CI, 0.69-0.99) and allergic rhinitis (OR, 0.85; 95% CI, 0.74-0.97). Higher maternal wheat intake during the second trimester was associated with reduced atopic dermatitis (OR, 0.64; 95% CI, 0.46-0.90). Peanut, wheat, and soy allergy were each cross-sectionally associated with increased childhood asthma, atopic dermatitis, and allergic rhinitis (ORs, 3.6 to 8.1).Conclusion
Higher maternal intake of peanut, milk, and wheat during early pregnancy was associated with reduced odds of mid-childhood allergy and asthma.
SUBMITTER: Bunyavanich S
PROVIDER: S-EPMC4004710 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Publications
Peanut, milk, and wheat intake during pregnancy is associated with reduced allergy and asthma in children.
The Journal of allergy and clinical immunology 20140209 5
<h4>Background</h4>Maternal diet during pregnancy may affect childhood allergy and asthma.<h4>Objective</h4>We sought to examine the associations between maternal intake of common childhood food allergens during early pregnancy and childhood allergy and asthma.<h4>Methods</h4>We studied 1277 mother-child pairs from a US prebirth cohort unselected for any disease. Using food frequency questionnaires administered during the first and second trimesters, we assessed maternal intake of common childho ...[more]