Ontology highlight
ABSTRACT:
SUBMITTER: Predeus AV
PROVIDER: S-EPMC4096788 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Journal of immunology (Baltimore, Md. : 1950) 20131218 3
The assembly and expression of mouse Ag receptor genes are controlled by a collection of cis-acting regulatory elements, including transcriptional promoters and enhancers. Although many powerful enhancers have been identified for Ig (Ig) and TCR (Tcr) loci, it remained unclear whether additional regulatory elements remain undiscovered. In this study, we use chromatin profiling of pro-B cells to define 38 epigenetic states in mouse Ag receptor loci, each of which reflects a distinct regulatory po ...[more]