Five-year incidence, progression, and risk factors for age-related macular degeneration: the age, gene/environment susceptibility study.

ABSTRACT:

Objective

To investigate the incidence and progression of age-related macular degeneration (AMD) and associated risk factors.

Design

Population-based, prospective, cohort study.

Participants

We included 2868 participants from the Age Gene/Environment Susceptibility-Reykjavik Study with retinal data at baseline and 5-year follow-up.

Methods

Digital macular photographs were graded for presence of AMD. Participants completed a questionnaire and extensive clinical battery. Biomarkers were assessed. Risk factors for AMD were analyzed using multivariate regression analysis with odds ratios (ORs) and 95% CIs.

Main outcome measures

We assessed AMD, defined as early or late.

Results

Among 2196 participants free of AMD at baseline, 14.9% developed incident

SUBMITTER: Jonasson F 

PROVIDER: S-EPMC4145014 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature