Endothelial lipase-384A/C polymorphism is associated with acute coronary syndrome and lipid status in elderly Uygur patients in Xinjiang.

ABSTRACT:

Objective

To explore the relationship between the endothelial lipase (EL) gene promoter -384A/C polymorphism and acute coronary syndrome (ACS) and lipid status in elderly Uygur patients in Xinjiang.

Methods

The polymerase chain reaction-restriction fragment length polymorphism method was used to detect the EL gene promoter -384A/C genotype in 341 cases of elderly patients with ACS and 380 healthy subjects.

Results

In an elderly Chinese Han population, the EL-384A/C genotype and allele frequency distribution were significantly different between the ACS group and the control group (p<0.05); the frequency of the CC genotype in the ACS group was significantly higher than that in the control group (p<0.05). After adjusting for gender, age, diabetes, hypertension, smoking,

SUBMITTER: Huang D 

PROVIDER: S-EPMC4216995 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature