Liver fibrosis is associated with cognitive impairment in HIV-positive patients.

ABSTRACT:

Introduction

The aim of our study was to investigate the potential relationship between liver fibrosis (LF) and cognitive performance in HIV+ patients.

Materials and methods

We performed a cross-sectional cohort study by consecutively enrolling HIV+ patients during routine outpatient visits at two clinical centres in Italy. Subjects with decompensated liver disease were excluded. All subjects underwent a comprehensive neuropsychological battery exploring memory, attention, psychomotor speed and language; cognitive impairment was defined as at least two abnormal [1.5 SD below the mean for appropriate norms] cognitive domains. LF was explored by calculating FIB4 index; in a subgroup of patients, LF was also assessed by transient elastography. Factors associated with cognitive

SUBMITTER: Ciccarelli N 

PROVIDER: S-EPMC4225249 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature