The defect of SFRP2 modulates an influx of extracellular calcium in B lymphocytes.
Ontology highlight
ABSTRACT: Background
In the Wnt pathway, the secreted frizzled-related protein 2 (SFRP2) is thought to act as one of the several competitive inhibitors of Wnt. However, the precise role of SFRP2 is still poorly understood especially in B lymphocytes. Here, we investigated the function of SFRP2, comparing the SFRP2 defective as well as normal B lymphocytes in mice.Results
We demonstrated that calcium influx from extracellular to intracellular space in splenic B cells was clearly affected by the defect of SFRP2. In addition, the phosphorylation of phospholipase Cγ2 was observed to be reduced in SFRP2 defective splenic B cells with B cell receptor stimulation.Conclusions
SFRP2 is suggested to modulate the influx from extracellular calcium in the B cell receptor signaling pathway.
SUBMITTER: Tokuda Y
PROVIDER: S-EPMC4242488 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Publications
The defect of SFRP2 modulates an influx of extracellular calcium in B lymphocytes.
Tokuda Yuichi Y Tanaka Masami M Yagi Tomohito T Tashiro Kei K
BMC research notes 20141104
<h4>Background</h4>In the Wnt pathway, the secreted frizzled-related protein 2 (SFRP2) is thought to act as one of the several competitive inhibitors of Wnt. However, the precise role of SFRP2 is still poorly understood especially in B lymphocytes. Here, we investigated the function of SFRP2, comparing the SFRP2 defective as well as normal B lymphocytes in mice.<h4>Results</h4>We demonstrated that calcium influx from extracellular to intracellular space in splenic B cells was clearly affected by ...[more]
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