Chronic alcohol self-administration in monkeys shows long-term quantity/frequency categorical stability.

ABSTRACT:

Background

The current criteria for alcohol use disorders (AUDs) do not include consumption (quantity/frequency) measures of alcohol intake, in part due to the difficulty of these measures in humans. Animal models of ethanol (EtOH) self-administration have been fundamental in advancing our understanding of the neurobiological basis of AUD and can address quantity/frequency measures with accurate measurements over prolonged periods of time. The nonhuman primate model of voluntary oral alcohol self-administration has documented both binge drinking and drinking to dependence and can be used to test the stability of consumption measures over time.

Methods

Here, an extensive set of alcohol intakes (g/kg/d) was analyzed from a large multi-cohort population of Rhesus (Macaca mulatt

SUBMITTER: Baker EJ 

PROVIDER: S-EPMC4244650 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature