Verapamil decreases the glucose-lowering effect of metformin in healthy volunteers.

ABSTRACT:

Aim

The organic cation transporter 1 (OCT1) plays a key role in the cellular transport of metformin and its subsequent glucose-lowering effect. A recent non-clinical study reported that metformin uptake into hepatocytes is regulated via OCT1, and that uptake was strongly inhibited by verapamil. Therefore, we investigated the effects of verapamil co-administration on the pharmacokinetics and pharmacodynamics of metformin in humans.

Methods

We evaluated the pharmacokinetics and the anti-hyperglycaemic effects of metformin using an oral glucose tolerance test (OGTT) in 12 healthy participants, before (day 1) and after metformin treatment (day 2), and again on days 15 and 16 after co-administration with verapamil.

Results

Verapamil inhibited the ability of metformin to re

SUBMITTER: Cho SK 

PROVIDER: S-EPMC4256631 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature