Effect of repeated bolus and continuous glucose infusion on a panel of circulating biomarkers in healthy volunteers.

ABSTRACT:

Hypothesis

Glycaemic variability (GV) refers to fluctuations in the blood glucose level and may contribute to complications in patients suffering from Diabetes. Several studies show negative effects of GV on the cardiovascular system, however there is still a lack of conclusive evidence. Using an explorative cardiovascular panel, it is possible to simultaneously measure the effects on proteins relevant for cardiovascular processes. The aim of this study was to investigate the effects of rapid glucose excursions on cardiovascular and metabolic parameters in healthy individuals.

Methods

An explorative single-blinded cross-over study was performed in ten healthy men. Subjects received 3 times 20 grams of glucose i.v. over 5 minutes or 60 grams of glucose continuously over 3 hou

SUBMITTER: Feldbauer R 

PROVIDER: S-EPMC9794098 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature