Dataset Information

Effect of repeated bolus and continuous glucose infusion on a panel of circulating biomarkers in healthy volunteers.

ABSTRACT:

Hypothesis

Glycaemic variability (GV) refers to fluctuations in the blood glucose level and may contribute to complications in patients suffering from Diabetes. Several studies show negative effects of GV on the cardiovascular system, however there is still a lack of conclusive evidence. Using an explorative cardiovascular panel, it is possible to simultaneously measure the effects on proteins relevant for cardiovascular processes. The aim of this study was to investigate the effects of rapid glucose excursions on cardiovascular and metabolic parameters in healthy individuals.

Methods

An explorative single-blinded cross-over study was performed in ten healthy men. Subjects received 3 times 20 grams of glucose i.v. over 5 minutes or 60 grams of glucose continuously over 3 hours. Blood was taken for repeated measurements of the cardiovascular panel over the following 6 hours and again after 24 and 48 hours.

Results

We observed a significant elevation of 7 cardiovascular biomarkers (BMP6, SLAMF7, LOX-1, ADAMTS13, IL-1RA, IL-4RA, PTX3) at t = 360min after rapid glucose infusion compared to a continuous glucose infusion.

Conclusions

Intraday GV seems to have acute effects on cardiovascular proteins in healthy test persons. Rapid glucose administration compared to continuous administration showed significant changes in BMP6, SLAMF7, ADAMTS13, IL1RA, PTX3, IL-4RA and LOX-1.

Clinical trial registration

NCT04488848.

SUBMITTER: Feldbauer R

PROVIDER: S-EPMC9794098 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

Effect of repeated bolus and continuous glucose infusion on a panel of circulating biomarkers in healthy volunteers.

Feldbauer Roland R Heinzl Matthias Wolfgang MW Klammer Carmen C Resl Michael M Pohlhammer Johannes J Rosenberger Klemens K Almesberger Verena V Obendorf Florian F Schinagl Lukas L Wagner Thomas T Egger Margot M Dieplinger Benjamin B Clodi Martin M

PloS one 20221227 12

<h4>Hypothesis</h4>Glycaemic variability (GV) refers to fluctuations in the blood glucose level and may contribute to complications in patients suffering from Diabetes. Several studies show negative effects of GV on the cardiovascular system, however there is still a lack of conclusive evidence. Using an explorative cardiovascular panel, it is possible to simultaneously measure the effects on proteins relevant for cardiovascular processes. The aim of this study was to investigate the effects of ...[more]

PMID: 36574434

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Dataset Information

Effect of repeated bolus and continuous glucose infusion on a panel of circulating biomarkers in healthy volunteers.

Hypothesis

Methods

Results

Conclusions

Clinical trial registration

Publications

Effect of repeated bolus and continuous glucose infusion on a panel of circulating biomarkers in healthy volunteers.

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