The expression of four genes as a prognostic classifier for stage I lung adenocarcinoma in 12 independent cohorts.

ABSTRACT:

Background

We previously developed a prognostic classifier using the expression levels of BRCA1, HIF1A, DLC1, and XPO1 that identified stage I lung adenocarcinoma patients with a high risk of relapse. That study evaluated patients in five independent cohorts from various regions of the world. In an attempt to further validate the classifier, we have used a meta-analysis-based approach to study 12 cohorts consisting of 1,069 tumor-node-metastasis stage I lung adenocarcinoma patients from every suitable, publically available dataset.

Methods

Cohorts were obtained through a systematic search of public gene expression datasets. These data were used to calculate the risk score using the previously published 4-gene risk model. A fixed effect meta-analysis model was used to generat

SUBMITTER: Okayama H 

PROVIDER: S-EPMC4257875 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature