Quantification of myocardial blood flow in absolute terms using (82)Rb PET imaging: the RUBY-10 Study.

ABSTRACT:

Objectives

The purpose of this study was to compare myocardial blood flow (MBF) and myocardial flow reserve (MFR) estimates from rubidium-82 positron emission tomography ((82)Rb PET) data using 10 software packages (SPs) based on 8 tracer kinetic models.

Background

It is unknown how MBF and MFR values from existing SPs agree for (82)Rb PET.

Methods

Rest and stress (82)Rb PET scans of 48 patients with suspected or known coronary artery disease were analyzed in 10 centers. Each center used 1 of 10 SPs to analyze global and regional MBF using the different kinetic models implemented. Values were considered to agree if they simultaneously had an intraclass correlation coefficient >0.75 and a difference <20% of the median across all programs.

Results

The most common

SUBMITTER: Nesterov SV 

PROVIDER: S-EPMC4260449 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature