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Intravenous thiamine is associated with increased oxygen consumption in critically ill patients with preserved cardiac index.


ABSTRACT: Oxygen consumption may be impaired in critically ill patients.To evaluate the effect of intravenous thiamine on oxygen consumption ([Formula: see text]o2) in critically ill patients.This was a small, exploratory open-label pilot study conducted in the intensive care units at a tertiary care medical center. Critically ill adults requiring mechanical ventilation were screened for enrollment. Oxygen consumption ([Formula: see text]o2) and cardiac index (CI) were recorded continuously for 9 hours. After 3 hours of baseline data collection, 200 mg of intravenous thiamine was administered. The outcome was change in [Formula: see text]o2 after thiamine administration.Twenty patients were enrolled and 3 were excluded because of incomplete [Formula: see text]o2 data, leaving 17 patients for analysis. There was a trend toward increase in [Formula: see text]o2 after thiamine administration (16.3 ml/min, SE 8.5; P?=?0.052). After preplanned adjustment for changes in CI in case of a delivery-dependent state in some patients (with exclusion of one additional patient because of missing CI data), this became statistically significant (16.9 ml/min, SE 8.6; P?=?0.047). In patients with average CI greater than our cohort's mean value of 3 L/min/m(2), [Formula: see text]o2 increased by 70.9 ml/min (±16; P?

SUBMITTER: Berg KM 

PROVIDER: S-EPMC4298978 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

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Intravenous thiamine is associated with increased oxygen consumption in critically ill patients with preserved cardiac index.

Berg Katherine M KM   Gautam Shiva S   Salciccioli Justin D JD   Giberson Tyler T   Saindon Brian B   Donnino Michael W MW  

Annals of the American Thoracic Society 20141201 10


<h4>Rationale</h4>Oxygen consumption may be impaired in critically ill patients.<h4>Objectives</h4>To evaluate the effect of intravenous thiamine on oxygen consumption ([Formula: see text]o2) in critically ill patients.<h4>Methods</h4>This was a small, exploratory open-label pilot study conducted in the intensive care units at a tertiary care medical center. Critically ill adults requiring mechanical ventilation were screened for enrollment. Oxygen consumption ([Formula: see text]o2) and cardiac  ...[more]

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