Extramacrochaetae functions in dorsal-ventral patterning of Drosophila imaginal discs.

ABSTRACT: One of the seminal events in the history of a tissue is the establishment of the anterior-posterior, dorsal-ventral (D/V) and proximal-distal axes. Axis formation is important for the regional specification of a tissue and allows cells along the different axes to obtain directional and positional information. Within the Drosophila retina, D/V axis formation is essential to ensure that each unit eye first adopts the proper chiral form and then rotates precisely 90° in the correct direction. These two steps are important because the photoreceptor array must be correctly aligned with the neurons of the optic lobe. Defects in chirality and/or ommatidial rotation will lead to disorganization of the photoreceptor array, misalignment of retinal and optic lobe neurons, and loss of visual acuity. L

SUBMITTER: Spratford CM 

PROVIDER: S-EPMC4352973 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature