A multi-centre randomised trial comparing ultrasound vs mammography for screening breast cancer in high-risk Chinese women.

ABSTRACT:

Background

Chinese women tend to have small and dense breasts and ultrasound is a common method for breast cancer screening in China. However, its efficacy and cost comparing with mammography has not been evaluated in randomised trials.

Methods

At 14 breast centres across China during 2008-2010, 13 339 high-risk women aged 30-65 years were randomised to be screened by mammography alone, ultrasound alone, or by both methods at enrollment and 1-year follow-up.

Results

A total of 12 519 and 8692 women underwent the initial and second screenings, respectively. Among the 30 cancers (of which 15 were stage 0/I) detected, 5 (0.72/1000) were in the mammography group, 11 (1.51/1000) in the ultrasound group, and 14 (2.02/1000) in the combined group (P=0.12). In the combined gro

SUBMITTER: Shen S 

PROVIDER: S-EPMC4366890 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature