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ABSTRACT:
SUBMITTER: Miura F
PROVIDER: S-EPMC4379973 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Miura Fumihito F Ito Takashi T
DNA research : an international journal for rapid publication of reports on genes and genomes 20141016 1
The current gold standard method for methylome analysis is whole-genome bisulfite sequencing (WGBS), but its cost is substantial, especially for the purpose of multi-sample comparison of large methylomes. Shotgun bisulfite sequencing of target-enriched DNA, or targeted methylome sequencing (TMS), can be a flexible, cost-effective alternative to WGBS. However, the current TMS protocol requires a considerable amount of input DNA and hence is hardly applicable to samples of limited quantity. Here w ...[more]