Vitamin D receptor gene Tru9I polymorphism and risk for incidental sporadic colorectal adenomas.

ABSTRACT:

Aim

Recent laboratory and epidemiological studies suggest that vitamin D is a potential agent for colorectal cancer prevention. Its function is partially mediated by the vitamin D receptor (VDR). The aim of this study was to investigate whether a novel G (allele "U") >A (allele "u") polymorphism (Tru9I) in the VDR intron 8 region is associated with risk for colorectal adenoma in a colonoscopy-based case-control study.

Methods

Genotyping for a total of 391 subjects was carried out through PCR and restriction fragment length polymorphism.

Results

The frequencies of "U" and "u" alleles were 89.3% and 10.7%, respectively. The "Uu" and "uu" genotypes were associated with decreased risk for adenoma (OR, 0.71; 95%CI, 0.40-1.25). The inverse association was more pronounced fo

SUBMITTER: Gong YL 

PROVIDER: S-EPMC4398724 | biostudies-literature | 2005 Aug

REPOSITORIES: biostudies-literature