Anticancer activity of streptochlorin, a novel antineoplastic agent, in cholangiocarcinoma.

ABSTRACT:

Background

The aim of this study is to investigate the anticancer activity of streptochlorin, a novel antineoplastic agent, in cholangiocarcinoma.

Methods

The anticancer activity of streptochlorin was evaluated in vitro in various cholangiocarcinoma cell lines for apoptosis, proliferation, invasiveness, and expression of various protein levels. A liver metastasis model was prepared by splenic injection of HuCC-T1 cholangiocarcinoma cells using a BALB/c nude mouse model to study the systemic antimetastatic efficacy of streptochlorin 5 mg/kg at 8 weeks. The antitumor efficacy of subcutaneously injected streptochlorin was also assessed using a solid tumor xenograft model of SNU478 cells for 22 days in the BALB/c nude mouse.

Results

Streptochlorin inhibited growth and sec

SUBMITTER: Kwak TW 

PROVIDER: S-EPMC4404940 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature