Dataset Information

Functional Polymorphisms in COX-2 Gene Are Correlated with the Risk of Oral Cancer.

ABSTRACT:

Background

This meta-analysis investigated the association between functional COX-2 gene polymorphisms and the risk of oral cancer.

Methods

Several electronic databases were searched for published studies using combinations of keywords related to COX-2 gene polymorphisms and oral cancer. After selection of relevant studies, following strict inclusion and exclusion criteria, data was performed using STATA 12.0 software.

Results

We retrieved 83 studies from database search using specific search terms. After multiple rounds of selection and elimination, 7 studies were finally identified as suitable to be included in our present meta-analysis, based on their relevance and data integrity. These 7 studies contained a combined total of 2,296 oral cancer patients and 3,647 healthy controls. Our findings demonstrated that +837 T > C (rs5275) polymorphism in COX-2 showed statistically significant differences in gene frequencies in case and control groups in allele model and dominant model. Similar results were obtained with COX-2 gene polymorphism 765 G > C (rs20417). On the other hand, 1195 A > G (rs689466) polymorphism in COX-2 did not confer susceptibility to oral cancers.

Conclusion

Based on our results, COX-2 gene polymorphisms, +837 T > C (rs5275) and -765G > C (rs20417), showed clear links with oral cancer susceptibility, and the 1195A > G (rs689466) polymorphism did not show such a correlation.

SUBMITTER: Li D

PROVIDER: S-EPMC4419230 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Publications

Functional Polymorphisms in COX-2 Gene Are Correlated with the Risk of Oral Cancer.

Li Dong D Hao Shu-Hong SH Sun Yan Y Hu Chun-Mei CM Ma Zhi-Hua ZH Wang Zhi Ming ZM Liu Jie J Liu Hong Bo HB Ye Ming M Zhang Yu Fei YF Yang Dong Sheng DS Shi Guang G

BioMed research international 20150421

<h4>Background</h4>This meta-analysis investigated the association between functional COX-2 gene polymorphisms and the risk of oral cancer.<h4>Methods</h4>Several electronic databases were searched for published studies using combinations of keywords related to COX-2 gene polymorphisms and oral cancer. After selection of relevant studies, following strict inclusion and exclusion criteria, data was performed using STATA 12.0 software.<h4>Results</h4>We retrieved 83 studies from database search us ...[more]

PMID: 25977924

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Project description:Background/aimProgrammed cell death 6 (PDCD6) is up-regulated and highly expressed in early apoptotic cells. In several types of cancer, such as cervical, breast and lung cancers, the association of PDCD6 genotypes have been investigated. However, the contribution of PDCD6 variant genotypes to oral cancer has never been examined. The current study aimed to evaluate the contribution of the PDCD6 rs4957014 and rs3756712 genotypes to the risk of oral cancer in Taiwan.Patients and methodsThe contribution of PDCD6 genotypes to oral cancer risk was examined among 958 patients with lung cancer and 958 age- and sex-matched healthy controls by polymerase chain reaction-restriction fragment length polymorphism (PCR- RFLP).ResultsThe data showed that the hetero-variant GT and homo-variant GG genotypes of PDCD6 rs4957014 were associated with a decreased risk of oral cancer [odds ratio (OR)=0.81 and 0.39, 95% confidence interval (CI)=0.67-0.97 and 0.27-0.56, respectively]. The recessive and dominant models also showed that G carriers have protective effects (OR=0.43 and 0.72, 95% CI=0.30-0.61 and 0.61-0.87, respectively). The analysis of allelic frequency distributions showed that the G allele of PDCD6 rs4957014 was associated with reduced oral cancer risk (OR=0.71, 95% CI=0.62-0.82). There was no significant association between any PDCD6 rs3756712 genotype and oral cancer risk. In addition, the GG genotype at PDCD6 rs4957014 significantly decreased the risk of oral cancer among both males (adjusted OR=0.31, 95%CI=0.24-0.56) and females (adjusted OR=0.44, 95% CI=0.22-0.91). Furthermore, the GG genotype at PDCD6 rs4957014 significantly decreased the risk of oral cancer among smokers (adjusted OR=0.35, 95% CI=0.22-0.58), alcohol drinkers (adjusted OR=0.33, 95% CI=0.18-0.49), non-betel quid chewers (adjusted OR=0.33, 95% CI=0.17- 0.81), betel quid chewers (adjusted OR=0.34, 95% CI=0.21- 0.59), but not among never-smokers and non-alcohol drinkers.ConclusionThe G allele carriers of PDCD6 rs4957014 may have protective effects on oral cancer risk and serve as a practical marker for early detection of oral cancer in Taiwan.

Dataset Information

Functional Polymorphisms in COX-2 Gene Are Correlated with the Risk of Oral Cancer.

Background

Methods

Results

Conclusion

Publications

Functional Polymorphisms in COX-2 Gene Are Correlated with the Risk of Oral Cancer.

Similar Datasets

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