Virulence genes are a signature of the microbiome in the colorectal tumor microenvironment.

ABSTRACT:

Background

The human gut microbiome is associated with the development of colon cancer, and recent studies have found changes in the microbiome in cancer patients compared to healthy controls. Studying the microbial communities in the tumor microenvironment may shed light on the role of host-bacteria interactions in colorectal cancer. Here, we highlight the major shifts in the colorectal tumor microbiome relative to that of matched normal colon tissue from the same individual, allowing us to survey the microbial communities in the tumor microenvironment and providing intrinsic control for environmental and host genetic effects on the microbiome.

Methods

We sequenced the microbiome in 44 primary tumor and 44 patient-matched normal colon tissue samples to determine differentia

SUBMITTER: Burns MB 

PROVIDER: S-EPMC4499914 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature