Concept and design of a genome-wide association genotyping array tailored for transplantation-specific studies.

ABSTRACT:

Background

In addition to HLA genetic incompatibility, non-HLA difference between donor and recipients of transplantation leading to allograft rejection are now becoming evident. We aimed to create a unique genome-wide platform to facilitate genomic research studies in transplant-related studies. We designed a genome-wide genotyping tool based on the most recent human genomic reference datasets, and included customization for known and potentially relevant metabolic and pharmacological loci relevant to transplantation.

Methods

We describe here the design and implementation of a customized genome-wide genotyping array, the 'TxArray', comprising approximately 782,000 markers with tailored content for deeper capture of variants across HLA, KIR, pharmacogenomic, and metabolic lo

SUBMITTER: Li YR 

PROVIDER: S-EPMC4589899 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature