Class 3 semaphorins expression and association with innervation and angiogenesis within the degenerate human intervertebral disc.

ABSTRACT: Nerve and blood vessel ingrowth during intervertebral disc degeneration, is thought to be a major cause of low back pain, however the regulation of this process is poorly understood. Here, we investigated the expression and regulation of a subclass of axonal guidance molecules known as the class 3 semaphorins, and their receptors; plexins and neuropilins within human NP tissue and their regulation by pro-inflammatory cytokines. Importantly this determined whether semaphorin expression was associated with the presence of nerves and blood vessels in tissues from human intervertebral discs. The study demonstrated that semaphorin3A, 3C, 3D, 3E and 3F and their receptors were expressed by native NP cells and further demonstrated their expression was regulated by IL-1β but to a lesser extent by

SUBMITTER: Binch AL 

PROVIDER: S-EPMC4621894 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature