Complete Remission in the Nephrotic Syndrome Study Network.

ABSTRACT:

Background and objectives

This analysis from the Nephrotic Syndrome Study Network (NEPTUNE) assessed the phenotypic and pathology characteristics of proteinuric patients undergoing kidney biopsy and defined the frequency and factors associated with complete proteinuria remission (CRever).

Design, setting, participants, & measurements

We enrolled adults and children with proteinuria ≥0.5 g/d at the time of first clinically indicated renal biopsy at 21 sites in North America from April 2010 to June 2014 into a prospective cohort study. NEPTUNE central pathologists assigned participants to minimal-change disease (MCD), FSGS, membranous nephropathy, or other glomerulopathy cohorts. Outcome measures for this analysis were (1) CRever with urine protein-to-creatinine ratio (UPC) <0

SUBMITTER: Gipson DS 

PROVIDER: S-EPMC4702222 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature