Ontology highlight
ABSTRACT:
SUBMITTER: Ramirez M
PROVIDER: S-EPMC4762880 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Nature communications 20160219
Cancer therapy has traditionally focused on eliminating fast-growing populations of cells. Yet, an increasing body of evidence suggests that small subpopulations of cancer cells can evade strong selective drug pressure by entering a 'persister' state of negligible growth. This drug-tolerant state has been hypothesized to be part of an initial strategy towards eventual acquisition of bona fide drug-resistance mechanisms. However, the diversity of drug-resistance mechanisms that can expand from a ...[more]