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Influence of atherosclerosis-related risk factors on serum high-sensitivity C-reactive protein levels in patients with type 2 diabetes: Comparison of their influence in obese and non-obese patients.

ABSTRACT: AIMS/INTRODUCTION:Increased levels of high-sensitivity C-reactive protein (hs-CRP) likely leads to the development of atherosclerosis. Therefore, it is very important to know which factors largely influence hs-CRP levels. In the present study, we examined the influence of various atherosclerosis-related factors on hs-CRP levels in patients with type 2 diabetes. MATERIALS AND METHODS:A total of 275 patients (176 men, 99 women) were enrolled in this study. We tested the relationship between the number of risk factors reaching a desired value and hs-CRP levels. The Mann-Whitney U-test was used to compare two groups. The Kruskal-Wallis test was used to carry out overall group comparisons, and the Steel-Dwass test was used to carry out between-group comparisons. Spearman's rank correlation was carried out to study the correlation between hs-CRP levels and clinical parameters. Multivariate regression method was used to analyze the factors independently contributing to hs-CRP levels. RESULTS:Hs-CRP levels were lower in patients with a larger number of risk factors reaching a desired value. In particular, triglyceride and body mass index (BMI) were independent risk factors determining hs-CRP levels in a multivariate regression analysis. Furthermore, we compared the influence of various factors on hs-CRP levels in both obese (BMI ?25 kg/m(2)) and non-obese patients with type 2 diabetes (BMI <25 kg/m(2)). In obese groups, BMI and urinary albumin were independent risk factors determining hs-CRP levels, whereas triglyceride and statin were independent risk factors in non-obese patients. CONCLUSIONS:There is some difference in the factors responsible for hs-CRP levels in obese and non-obese patients with type 2 diabetes.

SUBMITTER: Shimoda M

PROVIDER: S-EPMC4773672 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Influence of atherosclerosis-related risk factors on serum high-sensitivity C-reactive protein levels in patients with type 2 diabetes: Comparison of their influence in obese and non-obese patients.

Shimoda Masashi M Kaneto Hideaki H Yoshioka Hiroshi H Okauchi Seizo S Hirukawa Hidenori H Kimura Tomohiko T Kanda-Kimura Yukiko Y Kohara Kenji K Kamei Shinji S Kawasaki Fumiko F Mune Tomoatsu T Kaku Kohei K

Journal of diabetes investigation 20150727 2

<h4>Aims/introduction</h4>Increased levels of high-sensitivity C-reactive protein (hs-CRP) likely leads to the development of atherosclerosis. Therefore, it is very important to know which factors largely influence hs-CRP levels. In the present study, we examined the influence of various atherosclerosis-related factors on hs-CRP levels in patients with type 2 diabetes.<h4>Materials and methods</h4>A total of 275 patients (176 men, 99 women) were enrolled in this study. We tested the relationship ...[more]

PMID: 27042271

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Project description:BackgroundHigh sensitivity C-reactive protein (hsCRP) levels are shown to be influenced by genetic variants in Europeans; however, little is explored in Indian population.MethodsHerein, we comprehensively evaluated association of all previously reported genetic determinants of hsCRP levels, including 18 cis (proximal to CRP gene) and 73 trans-acting (distal to CRP gene) variants in 4,200 North Indians of Indo-European ethnicity. First, we evaluated association of 91 variants from 12 candidate loci with hsCRP levels in 2,115 North Indians (1,042 non-diabetic subjects and 1,073 patients with type 2 diabetes). Then, cis and trans-acting variants contributing maximally to hsCRP level variation were further replicated in an independent 2,085 North Indians (1,047 patients with type 2 diabetes and 1,038 non-diabetic subjects).ResultsWe found association of 12 variants from CRP, LEPR, IL1A, IL6, and IL6R with hsCRP levels in non-diabetic subjects. However, only rs3093059-CRP [β = 0.33, P = 9.6×10⁻⁵] and the haplotype harboring rs3093059 risk allele [β = 0.32 µg/mL, P = 1.4×10⁻⁴/P(perm) = 9.0×10⁻⁴] retained significance after correcting for multiple testing. The cis-acting variant rs3093059-CRP had maximum contribution to the variance in hsCRP levels (1.14%). Among, trans-acting variants, rs1892534-LEPR was observed to contribute maximally to hsCRP level variance (0.59%). Associations of rs3093059-CRP and rs1892534-LEPR were confirmed by replication and attained higher significance after meta-analysis [β(meta) = 0.26/0.22; P(meta) = 4.3×10⁻⁷/7.4×10⁻³ and β(meta) = -0.15/-0.12; P(meta) = 2.0×10⁻⁶/1.6×10⁻⁶ for rs3093059 and rs1892534, respectively in non-diabetic subjects and all subjects taken together].ConclusionIn conclusion, we identified rs3093059 in CRP and rs1892534 in LEPR as major cis and trans-acting contributor respectively, to the variance in hsCRP levels in North Indian population.

Dataset Information

Influence of atherosclerosis-related risk factors on serum high-sensitivity C-reactive protein levels in patients with type 2 diabetes: Comparison of their influence in obese and non-obese patients.

Publications

Influence of atherosclerosis-related risk factors on serum high-sensitivity C-reactive protein levels in patients with type 2 diabetes: Comparison of their influence in obese and non-obese patients.

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