Ontology highlight
ABSTRACT:
SUBMITTER: Dorr CR
PROVIDER: S-EPMC4824450 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Dorr Casey R CR Freedman Barry I BI Hicks Pamela J PJ Brown W Mark WM Russell Gregory B GB Julian Bruce A BA Pastan Stephen O SO Gautreaux Michael D MD Muthusamy Amutha A Chinnakotla Srinath S Hauptfeld Vera V Bray Robert A RA Kirk Allan D AD Divers Jasmin J Israni Ajay K AK
PloS one 20160407 4
<h4>Background</h4>Apolipoprotein L1 gene (APOL1) G1 and G2 renal-risk variants, common in populations with recent African ancestry, are strongly associated with non-diabetic nephropathy, end-stage kidney disease, and shorter allograft survival in deceased-donor kidneys (autosomal recessive inheritance). Circulating APOL1 protein is synthesized primarily in the liver and hydrodynamic gene delivery of APOL1 G1 and G2 risk variants has caused hepatic necrosis in a murine model.<h4>Methods</h4>To e ...[more]