Dataset Information
Red blood cell transfusion is associated with increased hemolysis and an acute phase response in a subset of critically ill children.
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ABSTRACT:
SUBMITTER: L'Acqua C
PROVIDER: S-EPMC4831067 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
Red blood cell transfusion is associated with increased hemolysis and an acute phase response in a subset of critically ill children.
American journal of hematology 20151001 10
In healthy adults, transfusion of older stored red blood cells (RBCs) produces extravascular hemolysis and circulating non-transferrin-bound iron. In a prospective, observational study of critically ill children, we examined the effect of RBC storage duration on the extent of hemolysis by comparing laboratory measurements obtained before, and 4 hr after, RBC transfusion (N = 100) or saline/albumin infusion (N = 20). Transfusion of RBCs stored for longer than 4 weeks significantly increased plasm ...[more]