Association of glutathione S-transferases M1 and T1 gene polymorphisms with the risk of metabolic syndrome in an Iranian population.

ABSTRACT:

Background

Glutathione S-transferases (GSTs) are important factors in cell sensitivity to oxidative stress and susceptibility to cardiometabolic disorders. We aimed to investigate the GSTM1 and T1 gene polymorphisms, as well as their interactions in metabolic syndrome (MetS) patients and healthy individuals in an Iranian population.

Materials and methods

The study sample comprised of 220 healthy individuals (mean age: 41.9 - 15.1 years) and 165 MetS patients (mean age: 49.7 - 11.5 years). The diagnostic criteria for MetS were defined following the criteria provided by the modified National Cholesterol Education Program Adult Treatment Panel III. Genotyping of GSTM1 and T1 genes were performed using polymerase chain reaction.

Results

Our analyses have shown that neithe

SUBMITTER: Rafiee L 

PROVIDER: S-EPMC4832886 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature